Gosselies, Belgium – March 21, 2018 - iTeos Therapeutics is pleased to have been awarded the Trends Gazelles 2018 award for Wallonia. Trends Gazelles Ambassadors are fast-growing companies that have a significant positive impact on the competitiveness and business dynamics of their region.
iTeos Therapeutics SA, a drug discovery company focused on the development of immunomodulators for cancer therapy, today announced the successful closing of its Series A equity financing round. iTeos, a joint spin-off of the Ludwig Institute for Cancer Research (LICR) and the de Duve Institute at the Université catholique de Louvain (UCL), raised €3.0 million from LICR, Hunza Ventures SCA, Life Sciences Research Partners, VIVES Louvain Technology Fund and several business angels. This financing complements a €6 million non-dilutive grant from the Belgian Walloon Government, which was received in December 2011. Cancer immunotherapy has gained momentum in the two last years because of the clinical success of new immunotherapeutic treatments. Immunotherapy can harness the immune system to selectively destroy tumors and limit the risk of recurrences, with very limited side effects. However, the success of cancer immunotherapy has been limited by the ability of tumors to block the immune response, something known as immunosuppression. Scientists are now working to better understand the mechanisms responsible for immunosuppression, in order to devise strategies to overcome them. This is what iTeos’ research program strives to do: develop small-molecule immunomodulators that can increase the efficacy of cancer immunotherapy, as well as leverage the spontaneous anti-tumor immune response. “We believe that the efficacy of most cancer therapies — not only immunotherapy — will be greatly enhanced by the control of tumor immunosuppressive mechanisms,” said Benoît Van den Eynde, Brussels Branch Director at LICR, UCL Professor and co-founder of iTeos. “Our first strategy will aim to combine existing vaccines with new immunomodulators based on technology that was licensed from LICR. Thereafter we will explore combinations with other cancer therapies,” added Van den Eynde. “iTeos brings together the world-class expertise of LICR in immunotherapy and tumor immunology with a team of drug discovery experts to develop innovative treatments against severe diseases such as lung, pancreatic and liver cancers,” said iTeos co-founder and CEO Michel Detheux. “With substantial funding now in place, iTeos is well-positioned to execute its ambitious strategy over the next several years by accelerating the clinical development of its flagship program, as well as two additional preclinical programs,” added Detheux. “Moving early-stage research advances from LICR scientists into later-stage clinical testing for the benefit of patients is a priority for the Institute,” said Jonathan Skipper, Executive Director of Technology Development at LICR. “iTeos will have access to LICR’s expertise and infrastructure so that candidate therapeutics can be rapidly tested,” added Skipper. “We are very proud to establish a joint spin-off company between two prestigious institutes — LICR and the de Duve Institute at UCL. iTeos combines a solid pipeline with the expertise to develop a new discovery platform in immunomodulation," concluded Philippe Durieux, CEO of SOPARTEC and managing director of VIVES Louvain Technology Fund. The iTeos Board is comprised of industrial, scientific and financial experts, including Philippe Guinot as independent Chairman, Natacha Beaumont (Managing Director, Hunza Ventures), Chris Buyse (CFO, ThromboGenics), Philippe Durieux (VIVES) and Jonathan Skipper (Executive Director of Technology Development, LICR). The Scientific Committee comprises Jean-Yves Bonnefoy (VP R&D, Transgene), Pierre Coulie (UCL) and Douglas Fearon (Cambridge University). Eubelius was the legal advisor of the company in this transaction. All parties involved decided not to disclose any further financial information regarding this transaction. For more information, please visit www.iteostherapeutics.com or contact Michel Detheux at +32478034600, or by email at email@example.com. About iTeos Therapeutics SA Based in Gosselies, Belgium, iTeos Therapeutics SA is a private biotechnology company with a focus on developing small-molecule immunomodulators for cancer treatment. Originating from a partnership between the Ludwig Institute for Cancer Research and de Duve Institute at the Université catholique de Louvain, iTeos Therapeutics SA is led by management and research teams with proven track records in tumor immunology, immunotherapy, drug discovery and development. About Ludwig Institute for Cancer Research (LICR) LICR is an international non-profit organization committed to improving the understanding and control of cancer through integrated laboratory and clinical discovery. Leveraging its worldwide network of investigators and the ability to sponsor and conduct its own clinical trials, the Institute is actively engaged in translating its discoveries into applications for patient benefit. Since its establishment in 1971, the Institute has expended more than $1.5 billion on cancer research. For more information, please visit www.licr.org. About Life Sciences Research Partners Life Sciences Research Partners (formerly called D Collen Research Foundation) was founded by Emeritus Professor Désiré Collen in 1988. The purpose of Life Sciences Research Partners is, without any profit-making intentions, to carry out, promote and support scientific research in general and biomedical and biotechnological research in particular. The specific activities by which the purposes of the association will be realized are among others the awarding of research grants, research mandates and traveling scholarships, the organization of scientific congresses and symposia, financial support of publications, and any other related activities that support or help to propagate the advancement of science. In addition, the association may conduct any other activity, that contributes directly or indirectly to its non-profit purpose, including commercial and profitable activities within legal boundaries, on condition that the profit thereof be exclusively spent on the non-profit purposes of the association. For more information, please visit www.lsrp.be. About VIVES-Louvain Technology Fund VIVES-Louvain Technology Fund is a multi-sectorial technology investment fund that invests in spin-offs ofUniversité catholique de Louvain (UCL) as well as start-ups in Belgium and neighboring countries. The objective of the fund is to invest in the development of start-ups, from technological validation through to commercial maturity. The funds (VIVES 1 of EUR 15 mio and VIVES 2 of EUR 43mio) are managed by SOPARTEC, the technology transfer company of the Université catholique de Louvain (UCL). Through Louvain Technology Transfer Office (LTTO), SOPARTEC and the University´s Research Administration (ADRE) are in charge of the overall technology transfer process. This covers the financing of research contracts, the identification of inventions within the laboratories, the protection and management of intellectual property,the technological maturation and the commercialization (through licensing and/or spin-off). More specifically, SOPARTEC coordinates the management of licensing agreements and the technological maturation of UCL spin-offs. More than 50 spin-offs, which today generate more than 3,000 jobs, have been created in whole or part from the results of research conducted at the UCL. These include Ion Beam Application (IBA), I.R.I.S. Group, IbT, Telemis, Alterface, Cissoid, Viridaxis, Promethera, Greenwatt, etc. For more information, please visit http://www.vivesfund.com. About Hunza Ventures SCA Hunza Ventures is a venture capital firm dedicated to the life sciences and information technology currently managing in excess of €20 million. Founded in 1998, Hunza Ventures has built a balanced portfolio of companies developing novel approaches and best-in-class products. With its strong sector expertise and through its multidisciplinary team and entrepreneurial approach, the fund prides itself in truly partnering with its portfolio companies. For more information, please visit www.hunza-ventures.com. About UCL Founded in 1425, one of Europe’s oldest universities, UCL has 27,289 students on six sites (Louvain-la-Neuve, Bruxelles (Woluwe and Saint-Gilles), Mons, Tournai, Charleroi). UCL educates almost one in every two French-speaking Belgians, and attracts every year 4,000 international students from around the globe (a number of programmes are given in English). UCL trains students in all disciplines, from beginner’s level through doctorate level and on to adult continuing education. Teaching is based on solid research and innovation. UCL is also one of the 22 European Universities to have received the ECTS label, a European Union recognition of the quality of its management of international exchanges. In the latest QS World University Rankings (2011), UCL was located at the 125e position, which makes it the first French speaking university of Belgium. For more information, please visit www.uclouvain.be. About de Duve Institute Founded in 1974 by Nobel Prize Laureate Christian de Duve, the de Duve Institute is a renowned multidisciplinary biomedical research institute located on the Brussels campus of the Université catholique de Louvain (UCL), next to the Cliniques Universitaires Saint-Luc. It hosts several laboratories of the Faculty of Medicine of UCL, as well as the Brussels Branch of the Ludwig Institute for Cancer Research. Research priorities at the de Duve Institute are based on three principles: (i) priority to fundamental research and to the freedom of the investigators, (ii) special attention to medical benefits potentially resulting from fundamental discoveries (iii) multidisciplinary collaboration within a critical mass of competences. For more information, please visit www.deduveinstitute.be.
– Initial data from the dose escalation portion of the Phase 1/2a trial in 21 cancer patients with advanced solid tumors shows EOS-850 was well tolerated with no dose-limiting toxicities observed – – EOS-850 showed preliminary single-agent clinical benefit in seven patients who continue to present with at least stable disease; two partial responses in heavily-pretreated patients are ongoing – – Identification of recommended Phase 2 dose showing strong foundation for planned expansion cohorts to evaluate EOS-850 as a monotherapy and in combination for several solid tumor indications – Gosselies, Belgium and Cambridge, MA – April 27, 2020. iTeos Therapeutics, a privately-held clinical-stage biotechnology company developing novel cancer immunotherapies, announced today that it will present initial data from the Phase 1 portion of the study of its selective and differentiated A2A receptor antagonist, EOS-850, in a poster presentation at the American Association of Cancer Research (AACR) Virtual Annual Meeting 2020. “We are excited by these data from the Phase 1 portion of the study, in which our highly selective A2A antagonist, EOS-850, had a favorable tolerability profile, as well as promising clinical responses, in cancer patients with advanced solid tumors,” said Joanne Jenkins Lager, M.D., Chief Medical Officer of iTeos Therapeutics. “We have established a recommended Phase 2 dose that was well tolerated and demonstrated favorable target coverage. The single-agent activity, demonstrated by two partial responses in heavily pre-treated patients, shows that EOS-850 is an active drug with a good therapeutic index. These data set a strong foundation for moving into the next stage of development in several expansion cohorts, whether as a single agent or in combination with Merck’s KEYTRUDA® or chemotherapy standard of care agents.” The Phase 1 dose escalation portion of the EOS-850 trial enrolled 21 advanced cancer patients with solid tumors. The trial was a 3 + 3 design and patients were enrolled in five dose levels, receiving EOS-850 orally either once a day (QD) or twice a day (BID). Additional patients could be enrolled at previously cleared dose levels to better define safety, pharmacokinetics and pharmacodynamics. The dose levels tested were 20 mg and 40 mg QD, and 40 mg, 80 mg and 160 mg BID. The primary objectives of the Phase 1 portion of the study were to evaluate the safety and tolerability of EOS-850 and to determine a recommended Phase 2 dose. Secondary study objectives include pharmacokinetic and pharmacodynamic assessment of EOS-850 monotherapy and monotherapy efficacy activity of EOS-850. Summary of the Data Presented All QD and BID dose levels were well-tolerated with no grade 3 or 4 drug-related adverse events. No dose limiting toxicities were observed. Assessment of the pharmacodynamic effects of EOS-850 in assays assessing phosphorylation of CREB and cytokine production, performed by taking blood samples from patients at various time points following administration, demonstrated sustained inhibition of the A2A receptor. Pharmacokinetic analysis demonstrated good dose-proportionality through 80mg BID, the recommended Phase 2 dose. EOS-850 demonstrated preliminary evidence of single-agent activity in seven patients, each of whom had at least stable disease. Ongoing partial responses were seen in a patient with heavily pre-treated checkpoint inhibitor-refractory melanoma and in a patient with metastatic hormone- and chemotherapy-resistant prostate cancer. The abstract and video presentation details are as follows: Title: First in human study with EOS100850, a novel potent A2A antagonist, shows excellent tolerance and clinical benefit in immune resistant advanced cancers (CT152) Session: Phase I Clinical Trials Abstract #: 10228 Authors: Laurence Buisseret, et al. The video presentation and full abstract will be available on the AACR conference website as of 9:00 AM ET on Monday, April 27th. KEYTRUDA® is a registered trademark of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, N.J., USA. EOS-850 Further Clinical Development Plans The primary and secondary endpoints of the dose escalation portion of the Phase 1/2a trial have been met at the recommended Phase 2 dose of 80mg BID. Based on these results, as well as the partial responses observed in two cancer patients with advanced disease, the Company is moving into the expansion cohorts of the study. These cohorts will test EOS-850 as a single agent and in combination with KEYTRUDA® (pembrolizumab) and in combination with chemotherapy. Indications for testing include checkpoint-resistant melanoma, metastatic hormone-resistant prostate cancer, triple-negative breast cancer, endometrial cancer and non-small cell lung cancer. The combination studies will include a safety evaluation of the combinations and then enroll patients in two-stage tumor-specific expansions. Preliminary results of these expansions are expected in the first half of 2021. About iTeos Therapeutics iTeos Therapeutics is a privately-held, clinical-stage biopharmaceutical company dedicated to transforming the lives of people living with cancer by designing and developing next generation immunotherapies targeting two key resistance pathways to checkpoint therapy: the adenosine pathway and regulatory T cells (Tregs). The Company’s lead program, EOS-850, is a potentially best-in-class adenosine A2A receptor antagonist currently in a Phase 1/2a trial. Its second program, a fully human ADCC-enabling anti-TIGIT antibody (EOS-448), entered the clinic in February 2020. The Company recently closed a $125 million Series B-2 financing from leading biotech investors including RA Capital, Boxer Capital, MPM Capital, Janus Henderson Advisors, RTW Investments, Invus, HBM Partners, Fund+, Vives II, SRIW and SFPI . iTeos Therapeutics is headquartered in Cambridge, MA with a research center in Gosselies, Belgium. For more information, please visit www.iteostherapeutics.com. For further information, please contact: Michel Detheux, CEO iTeos Therapeutics SA firstname.lastname@example.org Amber Fennell, Paul Kidwell, Matthew Neal and Sukaina Virji Consilium Strategic Communications +44 203 709 5700 email@example.com Sarah McCabe and Zofia Mita Stern Investor Relations, Inc. + 1 212 362 1200 iTeos@sternir.com
Gosselies, Belgium and Cambridge, MA – April 20, 2020. iTeos Therapeutics, a privately-held biotechnology company developing novel cancer immunotherapies, announces today that it will present initial data on the first-in-human study of its highly innovative and differentiated A2A receptor antagonist, EOS-850 in a virtual poster presentation at the upcoming American Association of Cancer Research (AACR) Virtual Annual Meeting 2020, taking place April 27-28th. The abstract and video presentation details are as follows: Title: First in human study with EOS100850, a novel potent A2A antagonist, shows excellent tolerance and clinical benefit in immune resistant advanced cancers (CT152) Session: Phase I Clinical Trials Abstract #: 10228 Authors: Laurence Buisseret, et al. The video presentation and full abstract will be available on the AACR conference website from 9:00 AM ET on Monday, April 27th. For further information, please contact: Michel Detheux, CEO iTeos Therapeutics SA firstname.lastname@example.org Amber Fennell, Paul Kidwell, Matthew Neal and Sukaina Virji Consilium Strategic Communications +44 203 709 5700 email@example.com Sarah McCabe and Zofia Mita Stern Investor Relations, Inc. + 1 212 362 1200 iTeos@sternir.com