iTeos Therapeutics to Present at SVB Leerink 9th Annual Global Healthcare Conference
Corporate

iTeos Therapeutics to Present at SVB Leerink 9th Annual Global Healthcare Conference

Cambridge, MA and Gosselies, Belgium – February 18, 2020 – iTeos Therapeutics SA, a privately-held biotechnology company developing innovative cancer immunotherapies, today announced that Michel Detheux, Ph.D., president and chief executive officer, will present at the upcoming SVB Leerink 9th Annual Global Healthcare Conference on Tuesday, February 25, 2020 at 2:15 p.m. ET in New York, NY.

 

For further information, please contact:

Michel Detheux, CEO

iTeos Therapeutics

info@iteostherapeutics.com

 

Amber Fennell, Paul Kidwell, Matthew Neal and Sukaina Virji

Consilium Strategic Communications

+44 203 709 5700

iteos@consilium-comms.com

 

Sarah McCabe

Stern Investor Relations, Inc.

+1 212 362 1200

sarah.mccabe@sternir.com

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  • ITEOS THERAPEUTICS SA SECURED €9 MILLION FOR PRECLINICAL DRUG DEVELOPMENT
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    ITEOS THERAPEUTICS SA SECURED €9 MILLION FOR PRECLINICAL DRUG DEVELOPMENT

    iTeos Therapeutics SA, a drug discovery company focused on the development of immunomodulators for cancer therapy, today announced the successful closing of its Series A equity financing round. iTeos, a joint spin-off of the Ludwig Institute for Cancer Research (LICR) and the de Duve Institute at the Université catholique de Louvain (UCL), raised €3.0 million from LICR, Hunza Ventures SCA, Life Sciences Research Partners, VIVES Louvain Technology Fund and several business angels. This financing complements a €6 million non-dilutive grant from the Belgian Walloon Government, which was received in December 2011. Cancer immunotherapy has gained momentum in the two last years because of the clinical success of new immunotherapeutic treatments. Immunotherapy can harness the immune system to selectively destroy tumors and limit the risk of recurrences, with very limited side effects. However, the success of cancer immunotherapy has been limited by the ability of tumors to block the immune response, something known as immunosuppression. Scientists are now working to better understand the mechanisms responsible for immunosuppression, in order to devise strategies to overcome them. This is what iTeos’ research program strives to do: develop small-molecule immunomodulators that can increase the efficacy of cancer immunotherapy, as well as leverage the spontaneous anti-tumor immune response. “We believe that the efficacy of most cancer therapies — not only immunotherapy — will be greatly enhanced by the control of tumor immunosuppressive mechanisms,” said Benoît Van den Eynde, Brussels Branch Director at LICR, UCL Professor and co-founder of iTeos. “Our first strategy will aim to combine existing vaccines with new immunomodulators based on technology that was licensed from LICR. Thereafter we will explore combinations with other cancer therapies,” added Van den Eynde. “iTeos brings together the world-class expertise of LICR in immunotherapy and tumor immunology with a team of drug discovery experts to develop innovative treatments against severe diseases such as lung, pancreatic and liver cancers,” said iTeos co-founder and CEO Michel Detheux. “With substantial funding now in place, iTeos is well-positioned to execute its ambitious strategy over the next several years by accelerating the clinical development of its flagship program, as well as two additional preclinical programs,” added Detheux. “Moving early-stage research advances from LICR scientists into later-stage clinical testing for the benefit of patients is a priority for the Institute,” said Jonathan Skipper, Executive Director of Technology Development at LICR. “iTeos will have access to LICR’s expertise and infrastructure so that candidate therapeutics can be rapidly tested,” added Skipper. “We are very proud to establish a joint spin-off company between two prestigious institutes — LICR and the de Duve Institute at UCL. iTeos combines a solid pipeline with the expertise to develop a new discovery platform in immunomodulation," concluded Philippe Durieux, CEO of SOPARTEC and managing director of VIVES Louvain Technology Fund. The iTeos Board is comprised of industrial, scientific and financial experts, including Philippe Guinot as independent Chairman, Natacha Beaumont (Managing Director, Hunza Ventures), Chris Buyse (CFO, ThromboGenics), Philippe Durieux (VIVES) and Jonathan Skipper (Executive Director of Technology Development, LICR). The Scientific Committee comprises Jean-Yves Bonnefoy (VP R&D, Transgene), Pierre Coulie (UCL) and Douglas Fearon (Cambridge University). Eubelius was the legal advisor of the company in this transaction. All parties involved decided not to disclose any further financial information regarding this transaction. For more information, please visit www.iteostherapeutics.com or contact Michel Detheux at +32478034600, or by email at michel.detheux@iteostherapeutics.com. About iTeos Therapeutics SA Based in Gosselies, Belgium, iTeos Therapeutics SA is a private biotechnology company with a focus on developing small-molecule immunomodulators for cancer treatment. Originating from a partnership between the Ludwig Institute for Cancer Research and de Duve Institute at the Université catholique de Louvain, iTeos Therapeutics SA is led by management and research teams with proven track records in tumor immunology, immunotherapy, drug discovery and development. About Ludwig Institute for Cancer Research (LICR) LICR is an international non-profit organization committed to improving the understanding and control of cancer through integrated laboratory and clinical discovery. Leveraging its worldwide network of investigators and the ability to sponsor and conduct its own clinical trials, the Institute is actively engaged in translating its discoveries into applications for patient benefit. Since its establishment in 1971, the Institute has expended more than $1.5 billion on cancer research. For more information, please visit www.licr.org. About Life Sciences Research Partners Life Sciences Research Partners (formerly called D Collen Research Foundation) was founded by Emeritus Professor Désiré Collen in 1988. The purpose of Life Sciences Research Partners is, without any profit-making intentions, to carry out, promote and support scientific research in general and biomedical and biotechnological research in particular. The specific activities by which the purposes of the association will be realized are among others the awarding of research grants, research mandates and traveling scholarships, the organization of scientific congresses and symposia, financial support of publications, and any other related activities that support or help to propagate the advancement of science. In addition, the association may conduct any other activity, that contributes directly or indirectly to its non-profit purpose, including commercial and profitable activities within legal boundaries, on condition that the profit thereof be exclusively spent on the non-profit purposes of the association. For more information, please visit www.lsrp.be. About VIVES-Louvain Technology Fund VIVES-Louvain Technology Fund is a multi-sectorial technology investment fund that invests in spin-offs ofUniversité catholique de Louvain (UCL) as well as start-ups in Belgium and neighboring countries. The objective of the fund is to invest in the development of start-ups, from technological validation through to commercial maturity. The funds (VIVES 1 of EUR 15 mio and VIVES 2 of EUR 43mio) are managed by SOPARTEC, the technology transfer company of the Université catholique de Louvain (UCL). Through Louvain Technology Transfer Office (LTTO), SOPARTEC and the University´s Research Administration (ADRE) are in charge of the overall technology transfer process. This covers the financing of research contracts, the identification of inventions within the laboratories, the protection and management of intellectual property,the technological maturation and the commercialization (through licensing and/or spin-off). More specifically, SOPARTEC coordinates the management of licensing agreements and the technological maturation of UCL spin-offs. More than 50 spin-offs, which today generate more than 3,000 jobs, have been created in whole or part from the results of research conducted at the UCL. These include Ion Beam Application (IBA), I.R.I.S. Group, IbT, Telemis, Alterface, Cissoid, Viridaxis, Promethera, Greenwatt, etc. For more information, please visit http://www.vivesfund.com. About Hunza Ventures SCA Hunza Ventures is a venture capital firm dedicated to the life sciences and information technology currently managing in excess of €20 million. Founded in 1998, Hunza Ventures has built a balanced portfolio of companies developing novel approaches and best-in-class products. With its strong sector expertise and through its multidisciplinary team and entrepreneurial approach, the fund prides itself in truly partnering with its portfolio companies. For more information, please visit www.hunza-ventures.com. About UCL Founded in 1425, one of Europe’s oldest universities, UCL has 27,289 students on six sites (Louvain-la-Neuve, Bruxelles (Woluwe and Saint-Gilles), Mons, Tournai, Charleroi). UCL educates almost one in every two French-speaking Belgians, and attracts every year 4,000 international students from around the globe (a number of programmes are given in English). UCL trains students in all disciplines, from beginner’s level through doctorate level and on to adult continuing education. Teaching is based on solid research and innovation. UCL is also one of the 22 European Universities to have received the ECTS label, a European Union recognition of the quality of its management of international exchanges. In the latest QS World University Rankings (2011), UCL was located at the 125e position, which makes it the first French speaking university of Belgium. For more information, please visit www.uclouvain.be. About de Duve Institute Founded in 1974 by Nobel Prize Laureate Christian de Duve, the de Duve Institute is a renowned multidisciplinary biomedical research institute located on the Brussels campus of the Université catholique de Louvain (UCL), next to the Cliniques Universitaires Saint-Luc. It hosts several laboratories of the Faculty of Medicine of UCL, as well as the Brussels Branch of the Ludwig Institute for Cancer Research. Research priorities at the de Duve Institute are based on three principles: (i) priority to fundamental research and to the freedom of the investigators, (ii) special attention to medical benefits potentially resulting from fundamental discoveries (iii) multidisciplinary collaboration within a critical mass of competences. For more information, please visit www.deduveinstitute.be.

  • iTeos Therapeutics Presents Preclinical Data for its Anti-TIGIT antibody, EOS-448, at the AACR II Virtual Annual Meeting 2020
    Clinical Trials Corporate Research TIGIT

    iTeos Therapeutics Presents Preclinical Data for its Anti-TIGIT antibody, EOS-448, at the AACR II Virtual Annual Meeting 2020

    – EOS-448 is being investigated in a Phase 1/2a clinical trial in advanced solid tumors and the dose escalation portion of the trial was initiated in February 2020 – – EOS-448 has shown potent antitumor activity and a favourable tolerability profile in preclinical studies –   Cambridge, MA and Gosselies, Belgium – June 22, 2020. iTeos Therapeutics, a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients, is presenting preclinical data for its investigational FcγR-engaging anti-TIGIT antibody, EOS-448, in a virtual poster presentation at the American Association of Cancer Research II (AACR II) Virtual Annual Meeting 2020, taking place June 22-24th. EOS-448 has demonstrated strong functional activity and a clean safety profile in its preclinical studies. iTeos enrolled the first patient in the dose escalation portion of its Phase 1/2a study with EOS-448 in February, 2020. “We are excited to have started the Phase 1 portion of our first-in-human studies with our  FcγR-engaging anti-TIGIT antibody, EOS-448, which has demonstrated strong antitumor activity both as single agent and in combination as well as a clean tolerability profile in preclinical studies,” said Michel Detheux, Chief Executive Officer of iTeos Therapeutics. “We believe EOS-448 has significant potential to be beneficial to cancer patients in the clinic, on the basis of its potent activity in restoring antitumor immunity in preclinical studies, supported by its multiple mechanisms of action, as well as by the latest clinical data reported for compounds of the same class.” Summary of the Data to be Presented EOS-448, a novel FcγR-engaging anti-TIGIT antibody, is shown to be highly potent and demonstrates strong anti-tumor activity and a clean safety profile in the preclinical setting. In addition to its ability to reverse immunosuppression of NK and effector T cells, EOS-448 is an IgG1 antibody, and has been able to induce potent and preferential cytotoxicity directed against Tregs as compared to CD4 and CD8 effector cells. Characterization of cell populations show that tumor-infiltrating Tregs exhibit differentially high levels of TIGIT, making these cells preferentially susceptible to ADCC. Furthermore, among tumor-infiltrating lymphocytes, or TILs, CD4 and CD8 T cells  expressing high levels of TIGIT typically display an exhausted profile. In preclinical tumor models of pre-established tumors, EOS-448 demonstrated strong tumor growth delay activity as a single agent and when combined with anti-PD-1 antibody, further increased the antitumor activity and resulted in complete responses in seven out of eight mice. The observed antitumor activity correlated with an increase of IFNγ-secreting CD4 and CD8 T cells and preferential Treg depletion within the tumor microenvironment. When the same anti-TIGIT clone was built on an antibody isotype with low FcγR binding capabilities and tested in the same model, or when our anti-TIGIT EOS-448 was dosed in FcγR knockout mice, antitumor activity was lost demonstrating the key role of FcγR engagement for the therapeutic activity of anti-TIGIT therapies. When tested in NHP, EOS-448 demonstrated a dose-proportional increase in exposure with a classical human IgG1 profile. The increase in exposure correlated with increased target engagement. We observed full occupancy of the TIGIT receptor which was maintained for at least 1 week at the highest tested dose. EOS-448 was shown to have a favorable tolerability profile  in these preclinical toxicology studies, and the NOAEL was the highest tested dose of 10mg/kg. The abstract and video presentation details are as follows: Title: Preparation of a clinical trial with a-TIGIT antagonist antibody EOS-448, which demonstrates potent preclinical activity and safe toxicology profile Session:  Immune Checkpoints 4 Abstract #: 3720 Poster #: 3161 Authors: Thi Lien-Anh Nguyen, et al. The abstract was posted online at 12:01 a.m. EDT on Friday, May 15 on the AACR conference website. The e-poster website will be launched today, June 22, the first day of the AACR Virtual Annual Meeting II. All e-posters will be made available for browsing on this date. EOS-448 Clinical Development (ClinicalTrials.gov Trial Identifier: NCT04335253) This Phase 1/2a study of EOS-448 is an open-label, dose-escalation study to assess the safety, pharmacokinetic, pharmacodynamic and preliminary clinical activity of EOS-448 in participants with advanced cancers. Participants’ tumors will be sampled before treatment and during treatment, to identify and confirm biomarkers to be used in further clinical development. Following dose escalation and determination of the recommended Phase 2 dose, the study design allows for the seamless expansion of patient cohorts to evaluate the anti-tumor activity of EOS-448 in specific tumor types. The trial will be conducted at multiple clinical sites in Europe and is expected to enroll approximately 30 patients with advanced cancer represented in the dose escalation portion. About iTeos Therapeutics iTeos Therapeutics is a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients. iTeos Therapeutics leverages its deep understanding of the tumor microenvironment and immunosuppressive pathways to design novel product candidates with an aim to improve the clinical benefit of oncology therapies. The innovative pipeline includes two clinical-stage programs targeting novel, validated immuno-oncology pathways designed to build on prior learnings in the field to have differentiated pharmacological and clinical profiles. The most advanced product candidate, EOS-850, is designed as a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors. EOS-850 is being investigated in an open-label Phase 1/2a clinical trial in adult patients with advanced solid tumors and encouraging preliminary single-agent activity were observed in the dose escalation portion of the trial. The lead antibody product candidate, EOS-448, is an antagonist of TIGIT, or T-cell immunoreceptor with Ig and ITIM domains, a checkpoint that has a role in both inhibitory and stimulatory pathways in the immune system. EOS-448 was also designed to engage the Fc gamma receptor, or FcγR, to promote antibody-dependent cellular cytotoxicity, or ADCC, activity, including the elimination of tumor-infiltrating regulatory T cells, or Tregs. An open-label Phase 1/2a clinical trial of EOS-448 was recently initiated in adult patients with advanced solid tumors. In April 2020, the Company  closed a $125 million Series B-2 financing from leading biotech investors including RA Capital, Boxer Capital, MPM Capital, Janus Henderson Advisors, RTW Investments, Invus, HBM Partners, Fund+, Vives II, SRIW and SFPI. iTeos Therapeutics is headquartered in Cambridge, MA with a research center in Gosselies, Belgium.  For further information, please contact:   Michel Detheux, CEO iTeos Therapeutics Inc info@iteostherapeutics.com   Amber Fennell, Paul Kidwell Consilium Strategic Communications +44 203 709 5700 iteos@consilium-comms.com   Sarah McCabe, Zofia Mita Stern Investor Relations, Inc. + 1 212 362 1200 iTeos@sternir.com  

  • iTeos Therapeutics Strengthens Leadership Team
    Corporate Financial Research

    iTeos Therapeutics Strengthens Leadership Team

    – Matthew Gall joins as Chief Financial Officer   – Dr Yvonne McGrath joins as Vice President of R&D  – Philippe Brantegem joins as Vice President of Human Resources  Cambridge, MA and Gosselies, Belgium – June 9, 2020 – iTeos Therapeutics Inc., a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients, announced today the appointments of Matthew Gall as Chief Financial Officer, Dr. Yvonne McGrath as Vice President of R&D and Philippe Brantegem as Vice President of Human Resources. “Matthew, Yvonne and Philippe are important additions to the growing iTeos Therapeutics leadership team and their unique skills and breadth and depth of experience will undoubtedly help to progress our pipeline, including our adenosine A2A receptor antagonist (EOS-850) and our anti-TIGIT antibody (EOS-448) programs, and position the company well for accelerated growth in the years to come,” said Michel Detheux, Chief Executive Officer of iTeos Therapeutics. “I am excited to join the iTeos team at this important time in the company’s growth. The talented personnel, highly differentiated immuno-oncology therapeutics and strong investors, position the company well as we pursue new treatments for people living with cancer,” said the new Chief Financial Officer of iTeos Therapeutics, Matthew Gall. Matthew Gall joins iTeos Therapeutics from Sarepta Therapeutics, Inc. where he was the Senior Vice President of Corporate Development and Treasurer. At Sarepta, Matthew led the Company’s recent multibillion partnership deal with Roche, and during his tenure, he oversaw the Company’s financial strategy and helped raise over $2 billion in capital. During his 15-year career in biotech, Matthew also worked at Celgene Corporation and Gilead Sciences in various roles including financial management and business development. Matthew holds an MBA from the University of Chicago Booth School of Business. Dr. Yvonne McGrath joins iTeos Therapeutics from Complix N.V. where she served as the Chief Scientific Officer. Yvonne has worked in the biotech industry for over 20 years, including a position as Head of Development at Immunocore, in addition to R&D management positions at Medigene and Biovex. Yvonne holds a Ph.D. from the University of Wales, College of Medicine, UK. Philippe Brantegem has delivered human resources support to biopharmaceutical companies such as Merck Sharp & Dohme, Besins Healthcare, Sanofi Pasteur MSD and Korn Ferry for over 20 years. Philippe holds master’s degrees in human resource management from the Université Libre de Bruxelles and in public administration from the Solvay Business School. About iTeos Therapeutics iTeos Therapeutics is a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of highly differentiated immuno-oncology therapeutics for patients. iTeos Therapeutics leverages its deep understanding of the tumor microenvironment and immunosuppressive pathways to design novel product candidates with an aim to improve the clinical benefit of oncology therapies. The innovative pipeline includes two clinical-stage programs targeting novel, validated immuno-oncology pathways designed to build on prior learnings in the field to have differentiated pharmacological and clinical profiles. The most advanced product candidate, EOS-850, is designed as a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors. EOS-850 is investigated in an open-label Phase 1/2a clinical trial in adult patients with advanced solid tumors and encouraging preliminary single-agent activity were observed in the dose escalation portion of the trial. The lead antibody product candidate, EOS-448, is an antagonist of TIGIT, or T-cell immunoreceptor with Ig and ITIM domains, a checkpoint that has a role in both inhibitory and stimulatory pathways in the immune system. EOS-448 was also designed to engage the Fc gamma receptor, or FcγR, to promote antibody-dependent cellular cytotoxicity, or ADCC, activity, including the elimination of tumor-infiltrating regulatory T cells, or Tregs. An open-label Phase 1/2a clinical trial of EOS-448 was recently initiated in adult patients with advanced solid tumors. In April 2020, the Company closed a $125 million Series B-2 financing from leading biotech investors including RA Capital, Boxer Capital, MPM Capital, Janus Henderson Advisors, RTW Investments, Invus, HBM Partners, Fund+, Vives II, SRIW and SFPI. iTeos Therapeutics is headquartered in Cambridge, MA with a research center in Gosselies, Belgium. For more information, please visit www.iteostherapeutics.com.   Michel Detheux, CEO iTeos Therapeutics, Inc. info@iteostherapeutics.com   Amber Fennell, Paul Kidwell Consilium Strategic Communications +44 203 709 5700 iteos@consilium-comms.com   Sarah McCabe and Zofia Mita Stern Investor Relations, Inc. +1 212 362 1200 iTeos@sternir.com